Itga4^em1Jifc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Itga4^em1Jifc
• Name: integrin alpha 4; endonuclease-mediated mutation 1, JianFeng Chen
• MGI ID: MGI:8402600
• Synonyms: Itga4^R985A
• Gene: Itga4 Location: Chr2:79085770-79163467 bp, + strand Genetic Position: Chr2, 47.38 cM
• Alliance: Itga4^em1Jifc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details:

  Arginine codon 1018 (AGG) was changed to alanine (GCG) (p.R1018A) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation blocks the binding of the encoded protein to Hsp90aa1 and Hsp90ab1, which impairs the fever-induced immune response to infections. (J:278096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga4 Mutation: 62 strains or lines available

References

• Original: J:278096 Lin C, et al., Fever Promotes T Lymphocyte Trafficking via a Thermal Sensory Pathway Involving Heat Shock Protein 90 and alpha4 Integrins. Immunity. 2019 Jan 15;50(1):137-151.e6
• All: 1 reference(s)