Phenotypes associated with this allele

• Allele Symbol: Mettl18^em1Yshk
• Allele Name: endonuclease-mediated mutation 1, Yoichi Shinkai
• Allele ID: MGI:8401220
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl18^em1Yshk/Mettl18^em1Yshk	C57BL/6J-Mettl18^em1Yshk	MGI:8401223

Genotype
MGI:8401223

hm1

• Allelic Composition: Mettl18^em1Yshk/Mettl18^em1Yshk
• Genetic Background: C57BL/6J-Mettl18^em1Yshk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:382377 )

growth/size/body

decreased body weight ( J:382377 )

• on a normal diet

• on a high fat diet weight catches up to wild-type mice on a normal diet but is still less than diet-matched wild-type controls

endocrine/exocrine glands

abnormal pancreas morphology ( J:382377 )

• decrease in global level of proteinaceous 3-methyl His in the pancreas

• however proteinaceous 1-methyl His is similar to controls

abnormal pancreas physiology ( J:382377 )

• phosphorylation and expression analysis indicates unfolded protein response activation and increased inflammatory cytokine expression

homeostasis/metabolism

increased circulating glucose level ( J:382377 )

• higher casual blood glucose level

• blood glucose levels remain higher than diet matched controls on a high fat diet

decreased circulating insulin level ( J:382377 )

• on a normal diet

• on a high fat diet serum insulin shows only a mild increase

impaired glucose tolerance ( J:382377 )

• marked glucose intolerance

• however, insulin sensitivity is similar to controls

increased insulin sensitivity ( J:382377 )

• on a high fat diet homozygous mice show better insulin response compared to diet matched controls

• no difference in insulin sensitivity on a normal diet

abnormal metabolism ( J:382377 )

• absence of RPL3 methylation at the N3 position of H245 in the pancreas, brain, liver, and kidney