Mettl18^em1Yshk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl18^em1Yshk
• Name: methyltransferase like 18; endonuclease-mediated mutation 1, Yoichi Shinkai
• MGI ID: MGI:8401220
• Gene: Mettl18 Location: Chr1:163822458-163824812 bp, + strand Genetic Position: Chr1, 71.3 cM
• Alliance: Mettl18^em1Yshk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination using guide RNAs targeting exon 2 resulted in two deletions of in the exon of nucleotides 1293-1685 and 1861-1872. (J:382377)

• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl18 Mutation: 18 strains or lines available

References

• Original: J:382377 Shimazu T, et al., METTL18 ensures pancreatic function by maintaining proper translation and proteostasis. Mol Metab. 2026 Feb 17;106:102337
• All: 1 reference(s)