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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thap1tm1.1Wtd
targeted mutation 1.1, William T Dauer
MGI:8395692
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Thap1tm1.1Wtd/Thap1tm1.1Wtd Not Specified MGI:8398135
ht2
 		Thap1tm1.1Wtd/Thap1tm1.2Meeh involves: 129S/SvEv MGI:8398137
cn3
 		Tg(Nes-cre)1Kln/0
Thap1tm1.1Wtd/Thap1tm1.2Meeh 		involves: 129S/SvEv * C57BL/6 * SJL MGI:8398140


Genotype
MGI:8398135
hm1
Allelic
Composition		 Thap1tm1.1Wtd/Thap1tm1.1Wtd
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1tm1.1Wtd mutation (0 available); any Thap1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:373524 )
N
• normal axonal density
dysmyelination ( J:373524 )
• fewer myelinated axons in corpus callosum (CC); demyelination of mostly smaller diameter axons
• thinner myelin sheath on myelinated axons




Genotype
MGI:8398137
ht2
Allelic
Composition		 Thap1tm1.1Wtd/Thap1tm1.2Meeh
Genetic
Background		 involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap1tm1.1Wtd mutation (0 available); any Thap1 mutation (34 available)
Thap1tm1.2Meeh mutation (0 available); any Thap1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:373524 )
• normal axonal density
dysmyelination ( J:373524 )
• fewer myelinated axons in corpus callosum (CC); demyelination of mostly smaller diameter axons
• thinner myelin sheath on myelinated axons




Genotype
MGI:8398140
cn3
Allelic
Composition		 Tg(Nes-cre)1Kln/0
Thap1tm1.1Wtd/Thap1tm1.2Meeh
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Thap1tm1.1Wtd mutation (0 available); any Thap1 mutation (34 available)
Thap1tm1.2Meeh mutation (0 available); any Thap1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:373524 )
• normal axonal density
dysmyelination ( J:373524 )
• fewer myelinated axons in corpus callosum (CC); demyelination of mostly smaller diameter axons
• thinner myelin sheath on myelinated axons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/08/2026
MGI 6.24 		The Jackson Laboratory