All Phenotypes Usp7<em1Gno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Usp7^em1Gno
endonuclease-mediated mutation 1, Gaia Novarino
MGI:8395601

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Usp7^em1Gno/Usp7⁺	C57BL/6J-Usp7^em1Gno	MGI:8395614

Allelic Composition	Usp7^em1Gno/Usp7⁺
Genetic Background	C57BL/6J-Usp7^em1Gno

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp7^em1Gno mutation (0 available); any Usp7 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal action potential ( J:389441 )

• mice exhibit altered intrinsic excitability and/or input-output (frequency-current) relationships in layer II/III somatosensory cortical pyramidal neurons at P7, showing increased action potential frequency with increased injected current

• maximal firing rate (Fmax), current at maximal firing rate (I@Fmax), membrane time constant (Tau), input resistance (Rin) and action potential after hyperpolarization (AHP) are affected

decreased miniature inhibitory postsynaptic current frequency ( J:389441 )

• mIPSC frequency is reduced in layer II/III somatosensory cortical pyramidal neurons at P7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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