Phenotypes associated with this allele

• Allele Symbol: Hnrnpu^tm1.2Tman
• Allele Name: targeted mutation 1.2, Tom Maniatis
• Allele ID: MGI:8395595
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hnrnpu^tm1.2Tman/Hnrnpu^+	involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6J	MGI:8395617

Genotype
MGI:8395617

ht1

• Allelic Composition: Hnrnpu^tm1.2Tman/Hnrnpu⁺
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:389441 )

• P13-15 mice exhibit motor impairments, including reduced speed, shorter stride and step lengths, and a trend towards reduced cross-correlation of forepaw movements during the walking phase

abnormal gait ( J:389441 )

• mice show abnormal hindpaw positioning during stride cycles

short stride length ( J:389441 )

cellular

increased cell proliferation ( J:389441 )

• E14.5 brain shows increased numbers of EdU+ radial glial cells, indicating prolonged proliferation and/or an expanded pool of proliferative radial glial cells

nervous system

abnormal action potential ( J:389441 )

• mice exhibit altered intrinsic excitability and/or input-output (frequency-current) relationships in layer II/III somatosensory cortical pyramidal neurons at P7, showing a slight reduction in action potential frequency at 10 pA to about 25 pA and then increased action potential frequency when injected current is over 30 pA

• current at maximal firing rate (I@Fmax) and full-width at half-maximum (FWHM) are affected