Hnrnpu^tm1.2Tman
Targeted Allele Detail

Summary

• Symbol: Hnrnpu^tm1.2Tman
• Name: heterogeneous nuclear ribonucleoprotein U; targeted mutation 1.2, Tom Maniatis
• MGI ID: MGI:8395595
• Gene: Hnrnpu Location: Chr1:178148673-178165362 bp, - strand Genetic Position: Chr1, 83.16 cM
• Alliance: Hnrnpu^tm1.2Tman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:389441
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details:

  A floxed neomycin resistance cassette was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 14. Cre-mediated recombination removed the selection cassette. Further cre-mediated recombination deleted exons 4-14. (J:389441)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpu Mutation: 44 strains or lines available

References

• Original: J:389441 Schwarz LA, et al., Cortical development dynamics across autism spectrum disorder mouse models. Nature. 2026 Jun 17
• All: 1 reference(s)