Phenotypes associated with this allele

• Allele Symbol: Thra^em1Lmoe
• Allele Name: endonuclease-mediated mutation 1, Lars C Moeller
• Allele ID: MGI:8394033
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^em1Lmoe/Thra^em1Lmoe	involves: C57BL/6J	MGI:8394322

Genotype
MGI:8394322

hm1

• Allelic Composition: Thra^em1Lmoe/Thra^em1Lmoe
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:253749 )

N • normal

growth/size/body

slow postnatal weight gain ( J:253749 )

decreased body length ( J:253749 )

• delayed linear growth at age P21

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:253749 )

N • normal hypoglycemic effect of active thyroid hormone (T3) injection

N • normal serum and liver triglyceride levels

skeleton

abnormal long bone epiphyseal ossification zone morphology ( J:253749 )

• delayed endochondral ossification: decrease in secondary ossification center size, increase in reserve zone width and decrease in hypertrophic zone at age P21

decreased length of long bones ( J:253749 )

• at age P21

abnormal vertebral epiphyseal plate morphology ( J:253749 )

• delayed endochondral ossification: decrease in secondary ossification center size, increase in reserve zone width and decrease in hypertrophic zone at age P21

short vertebral body ( J:253749 )

• at age P21

decreased bone mineral content ( J:253749 )

• in vertebrae at age P21

• normal in long bones at age P21

increased trabecular bone mass ( J:253749 )

• at age P21