Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-APPL1)F2Rnix
• Allele Name: transgene insertion F2, Ralph A Nixon
• Allele ID: MGI:8385888
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tg(Thy1-APPL1)F2Rnix/0	B6.Cg-Tg(Thy1-APPL1)F2Rnix	MGI:8385910

Genotype
MGI:8385910

ot1

• Allelic Composition: Tg(Thy1-APPL1)F2Rnix/0
• Genetic Background: B6.Cg-Tg(Thy1-APPL1)F2Rnix

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:389061 )

• hippocampal-dependent memory assessed by novel object recognition is impaired in 12-13-month-old mice

cellular

abnormal synaptic vesicle endocytosis ( J:389061 )

• age-dependent increase in synaptosomal endocytic uptake

nervous system

abnormal synaptic vesicle endocytosis ( J:389061 )

• age-dependent increase in synaptosomal endocytic uptake

abnormal neuron morphology ( J:389061 )

• age-dependent increase in neuronal early endosome size

abnormal cerebral cortex pyramidal cell morphology ( J:389061 )

• higher level of active rab5 immunolabeling is seen in cortical layer V neurons indicating an increase in active, early endosomes in 22-23-month-old mice

• early endosome size and early endosome area/cell are increased in 12-13 month and older age groups in cortical layer V neurons

abnormal cholinergic neuron morphology ( J:389061 )

• age-dependent loss of basal forebrain cholinergic neurons as indicated by reduced number of choline acetyltransferase (ChAT+) neurons in the medial septal nucleus, with reduced numbers first detected at 12 months of age

• medial septal nucleus neurons of 18-month-old mice exhibit abnormal, tortuous proximal dendrites and shrunken cholinergic cell soma

• accumulation of early endosomes in cholinergic neurons

abnormal synaptic bouton morphology ( J:389061 )

• mice show endocytic abnormalities in hippocampal synaptosomes

• phosphorylated tau is increased in hippocampal synaptosomes

abnormal dendrite morphology ( J:389061 )

• accumulation of endosomes and endosome size increase in cortical dendritic areas of 18-month-old mice

neurodegeneration ( J:389061 )

• age-dependent loss of basal forebrain cholinergic neurons

• however, levels of amyloid beta 40 and amyloid beta 42 are unchanged in 7-9- and 12-13-month-old mice

impaired synaptic plasticity ( J:389061 )

• mice show reduced hippocampal synaptic plasticity, with disruption of both hippocampal CA1 long-term potentiation (LTP) and long-term depression (LTD)

reduced long-term potentiation ( J:389061 )

• CA1 hippocampal slices show LTP impairment following TBS stimulation in 12-13-month-old mice but not in 7-9-month-old mice

reduced long-term depression ( J:389061 )

• postsynaptic potential (fEPSP) slopes show suppressed LTD upon induction by low frequency stimulation in 12-13-month-old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:389061