Tg(Thy1-APPL1)F2Rnix
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPL1)F2Rnix
• Name: transgene insertion F2, Ralph A Nixon
• MGI ID: MGI:8385888
• Synonyms: Thy1-APPL1
• Transgene: Tg(Thy1-APPL1)F2Rnix Location: unknown
• Alliance: Tg(Thy1-APPL1)F2Rnix page

Mutation origin

• Strain of Origin: 129 or C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPL1)F2Rnix expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APPL1 (26060)

  Appl1

  (MGI:1920243)

• Tg(Thy1-APPL1)F2Rnix expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Thy1 (MGI:98747)

• Mutation details:

  The transgenic construct contains a mouse Thy1 promotor directing expression of FLAG-tagged human APPL1 coding sequence. APPL1 overexpression was confirmed by Western blot analysis. (J:389061)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:389061 Jiang Y, et al., Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration. J Neurosci. 2025 Jul 16;45(29)
• All: 1 reference(s)