Phenotypes associated with this allele

• Allele Symbol: Cpe^em1Yplo
• Allele Name: endonuclease-mediated mutation 1, Y Peng Loh
• Allele ID: MGI:8385038
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpe^em1Yplo/Cpe^em1Yplo	C57BL/6-Cpe^em1Yplo	MGI:8385101

Genotype
MGI:8385101

hm1

• Allelic Composition: Cpe^em1Yplo/Cpe^em1Yplo
• Genetic Background: C57BL/6-Cpe^em1Yplo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:388991 )

N • normal behavior in Morris water maze test

N • normal behavior in elevated plus maze test

abnormal sucrose solution preference ( J:388991 )

• decreased preference for sucrose

increased depression-related behavior ( J:388991 )

• decreased speed and distance traveled in open field test

• longer period of immobility in forced swim test

decreased locomotor activity ( J:388991 )

• in open field test

• longer period of immobility in forced swim test

growth/size/body

increased body weight ( J:388991 )

homeostasis/metabolism

increased fasting circulating glucose level ( J:388991 )

decreased circulating insulin level ( J:388991 )

nervous system

nervous system phenotype ( J:388991 )

N • no neuronal degeneration in hippocampus, hypothalamus or prefrontal cortex after weaning stress

reproductive system

infertility ( J:388991 )

• no offspring in hom x hom or het (M/F) x hom (F/M) matings