Phenotypes associated with this allele

• Allele Symbol: Mettl3^em1Sxiao
• Allele Name: endonuclease-mediated mutation 1, Shan Xiao
• Allele ID: MGI:8352302
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl3^em1Sxiao/Mettl3^em1Sxiao	involves: C57BL/6	MGI:8352880
ht2	Mettl3^em1Sxiao/Mettl3^+	involves: C57BL/6	MGI:8352879

Genotype
MGI:8352880

hm1

• Allelic Composition: Mettl3^em1Sxiao/Mettl3^em1Sxiao
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:385020 )

Genotype
MGI:8352879

ht2

• Allelic Composition: Mettl3^em1Sxiao/Mettl3⁺
• Genetic Background: involves: C57BL/6

behavior/neurological

increased freezing behavior ( J:385020 )

• prolonged immobility in tail suspension test

impaired limb coordination ( J:385020 )

• increased climbing time in pole test at age 6 months

weakness ( J:385020 )

• increased climbing time in pole test at age 6 months

short stride length ( J:385020 )

• in open field and step distance tests at age 6 months

decreased locomotor activity ( J:385020 )

• in open field and step distance tests at age 6 months

cellular

decreased mitochondrial DNA content ( J:385020 )

• reduced copy number in substantia nigra

abnormal DNA-templated transcription ( J:385020 )

• reduction in methylated alanine in polyadenylated RNA in substantia nigra at age 6 months

• normal level of methylated alanine in polyadenylated RNA in substantia nigra at age 2 months

abnormal cellular respiration ( J:385020 )

• lower basal respiration and maximal oxygen consumption rate in embryonic stem cells

oxidative stress ( J:385020 )

• higher reactive oxygen species level in mitochondria in embryonic stem cells

nervous system

loss of dopaminergic neurons ( J:385020 )

• reduction in tyrosine hydroxylase (Th)-positive neurons in substantia nigra at age 6 months

• normal number of tyrosine hydroxylase (Th)-positive neurons in substantia nigra at age 2 months

taste/olfaction

impaired olfaction ( J:385020 )

• reduced tendency to sniff female urine and more time spent in hexanone-containing chamber

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinsonism		DOID:0080855		J:385020