Phenotypes associated with this allele

• Allele Symbol: Ank3^em1Ruiya
• Allele Name: endonuclease-mediated mutation 1, Rui Yang
• Allele ID: MGI:8350146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ank3^em1Ruiya/Ank3^em1Ruiya	Not Specified	MGI:8350158

Genotype
MGI:8350158

hm1

• Allelic Composition: Ank3^em1Ruiya/Ank3^em1Ruiya
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:385905 )

N • normal behavior in Morris water maze test

N • no preference for edges in open field test

N • normal preference for caged mice versus empty cage in sociability test

N • normal preference for novel mice versus familiar mice in social novelty test

abnormal behavior ( J:385905 )

♂ • fewer urine marks left around estrous female urine spot by sexually primed males pheromone-induced urine territory-marking assay

increased anxiety-related response ( J:385905 )

• more marbles buried in marble burying test

impaired coordination ( J:385905 )

• reduced latency to fall in rotarod test

abnormal gait ( J:385905 )

• wide stride

long stride length ( J:385905 )

decreased locomotor activity ( J:385905 )

• shorter total distance traveled in open field test

hyperactivity ( J:385905 )

• more marbles buried in marble burying test

nervous system

nervous system phenotype ( J:385905 )

N • normal miniature inhibitory postsynaptic current (mIPSC) frequency and amplitude in layer II/III pyramidal neurons in primary motor cortex at age P60

abnormal axon initial segment morphology ( J:385905 )

• longer in hippocampal neurons

increased dendritic spine density ( J:385905 )

• in layer II/III pyramidal neurons in primary motor cortex at age P60

abnormal action potential ( J:385905 )

• higher frequency and membrane resting potential and shorter half-width after current injection in layer II/III pyramidal neurons in primary motor cortex at age P60

• normal amplitude after current injection in layer II/III pyramidal neurons in primary motor cortex at age P60

increased excitatory postsynaptic current frequency ( J:385905 )

• increased miniature excitatory postsynaptic current (mEPSC) frequency in layer II/III pyramidal neurons in primary motor cortex at age P60

• normal miniature excitatory postsynaptic current (mEPSC) amplitude in layer II/III pyramidal neurons in primary motor cortex at age P60

taste/olfaction

taste/olfaction phenotype ( J:385905 )

N • normal behavior in buried-food-seeking test