Phenotypes associated with this allele

• Allele Symbol: Gramd4^em1Mnz
• Allele Name: endonuclease-mediated mutation 1, Michel C Nussenzweig
• Allele ID: MGI:8331909
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gramd4^em1Mnz/Gramd4^em1Mnz	C57BL/6J-Gramd4^em1Mnz	MGI:8331941

Genotype
MGI:8331941

hm1

• Allelic Composition: Gramd4^em1Mnz/Gramd4^em1Mnz
• Genetic Background: C57BL/6J-Gramd4^em1Mnz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased T cell proliferation ( J:352176 )

• increased number of adoptively transferred OT-II cells in draining lymph nodes after stimulation with chicken ovalbumin peptide (OVA328-339)

hematopoietic system

increased dendritic cell number ( J:352176 )

• increased proportion of mutant DCs (except migratory cDC2) compared to wild-type in bone marrow, spleen and inguinal lymph nodes in 1:1 mutant:wild-type chimeric bone marrow transfer experiment

abnormal T cell activation ( J:352176 )

• higher levels of CD69 and lower levels of CD43 in OT-II cells in draining lymph nodes after stimulation with chicken ovalbumin peptide (OVA328-339)

increased T cell proliferation ( J:352176 )

• increased number of adoptively transferred OT-II cells in draining lymph nodes after stimulation with chicken ovalbumin peptide (OVA328-339)

immune system

increased dendritic cell number ( J:352176 )

• increased proportion of mutant DCs (except migratory cDC2) compared to wild-type in bone marrow, spleen and inguinal lymph nodes in 1:1 mutant:wild-type chimeric bone marrow transfer experiment

abnormal T cell activation ( J:352176 )

• higher levels of CD69 and lower levels of CD43 in OT-II cells in draining lymph nodes after stimulation with chicken ovalbumin peptide (OVA328-339)

increased T cell proliferation ( J:352176 )

• increased number of adoptively transferred OT-II cells in draining lymph nodes after stimulation with chicken ovalbumin peptide (OVA328-339)