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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pfkfb2tm2Ntang
targeted mutation 2, Nan Tang
MGI:8328377
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Pfkfb2tm2Ntang/Pfkfb2tm2Ntang
Sftpctm1(cre/ERT2)Blh/Sftpc+
Stk11tm1.1Sjm/Stk11tm1.1Sjm 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:8329627
cn2
 		Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Pfkfb2tm2Ntang/Pfkfb2tm2Ntang
Sftpctm1(cre/ERT2)Blh/Sftpc+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:8329628


Genotype
MGI:8329627
cn1
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Pfkfb2tm2Ntang/Pfkfb2tm2Ntang
Sftpctm1(cre/ERT2)Blh/Sftpc+
Stk11tm1.1Sjm/Stk11tm1.1Sjm
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1205 available)
Pfkfb2tm2Ntang mutation (0 available); any Pfkfb2 mutation (37 available)
Sftpctm1(cre/ERT2)Blh mutation (1 available); any Sftpc mutation (25 available)
Stk11tm1.1Sjm mutation (1 available); any Stk11 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )
• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

mortality/aging
abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )
• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months




Genotype
MGI:8329628
cn2
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Pfkfb2tm2Ntang/Pfkfb2tm2Ntang
Sftpctm1(cre/ERT2)Blh/Sftpc+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1205 available)
Pfkfb2tm2Ntang mutation (0 available); any Pfkfb2 mutation (37 available)
Sftpctm1(cre/ERT2)Blh mutation (1 available); any Sftpc mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )
• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

mortality/aging
abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )
• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/12/2026
MGI 6.24 		The Jackson Laboratory