Analysis Tools
behavior/neurological
|
• in the novel object recognition test, mice spend less time exploring the novel object than controls indicating a memory deficit
• under hypoxia, mice spend much less time in exploring the novel object than control mice in the novel object recognition test
|
|
• in the Y maze, mice exhibit a tendency to spend less time in the novel arm compared with controls
• under hypoxia, mice exhibit greater loss of exploring tendency in the novel arm of the Y maze than controls
|
|
• in the novel object recognition test, mice spend less time exploring the novel object than controls indicating a memory deficit
• under hypoxia, mice spend much less time in exploring the novel object than control mice in the novel object recognition test
|
nervous system
|
• brain shows extravascular accumulation of FITC-dextran (40 kDa) in 3-month-old mice, indicating defective blood brain barrier (BBB)
• leakage of a larger molecule tracer (70 kDa) is not seen as the tracer is constrained to the vessels of the brain
• extravascular fibrin (about 50-50 kDa), but not IgG (about 150 kDa), is detected sporadically in the brain of 3-month-old mice
• extravascular accumulation of both 40 kDa and 70 kDa FITC-dextran tracer is detected in the brain of 3-month-old mice after exposure to 10% oxygen for 7 days indicating aggravated hypoxia-induced BBB disruption
• 3-fold increase in parenchymal accumulation of fibrin and leakage of circulating IgG is detected sporadically in the brain after exposure to prolonged hypoxia
|
|
• brains of 3-month-old mice show approximately 20% reduction in NeuN+ cells in the cortex and CA1 hippocampal subfield
|
|
• severe vascular leakage of FITC-dextran (40 kDa) is seen in the eyes, indicating defective integrity of blood-retina barrier (BRB
• leakage of a larger molecule tracer (70 kDa) is not seen as the tracer is constrained to the vessels of the retina
|
homeostasis/metabolism
|
• extravascular accumulation of both 40 kDa and 70 kDa FITC-dextran tracer is detected in the brain of 3-month-old mice after exposure to 10% oxygen for 7 days
• 3-fold increase in parenchymal accumulation of fibrin and leakage of circulating IgG is detected sporadically in the brain after exposure to prolonged hypoxia
|
cardiovascular system
|
• brain shows extravascular accumulation of FITC-dextran (40 kDa) in 3-month-old mice, indicating defective blood brain barrier (BBB)
• leakage of a larger molecule tracer (70 kDa) is not seen as the tracer is constrained to the vessels of the brain
• extravascular fibrin (about 50-50 kDa), but not IgG (about 150 kDa), is detected sporadically in the brain of 3-month-old mice
• extravascular accumulation of both 40 kDa and 70 kDa FITC-dextran tracer is detected in the brain of 3-month-old mice after exposure to 10% oxygen for 7 days indicating aggravated hypoxia-induced BBB disruption
• 3-fold increase in parenchymal accumulation of fibrin and leakage of circulating IgG is detected sporadically in the brain after exposure to prolonged hypoxia
|
vision/eye
|
• severe vascular leakage of FITC-dextran (40 kDa) is seen in the eyes, indicating defective integrity of blood-retina barrier (BRB
• leakage of a larger molecule tracer (70 kDa) is not seen as the tracer is constrained to the vessels of the retina
|
