Snhg12^tm1.1Chyh
Targeted Allele Detail

Summary

• Symbol: Snhg12^tm1.1Chyh
• Name: small nucleolar RNA host gene 12; targeted mutation 1.1, Yu-Hua Chen
• MGI ID: MGI:8326854
• Synonyms: Snhg12^loxP
• Gene: Snhg12 Location: Chr4:132035989-132038335 bp, + strand Genetic Position: Chr4, 65.16 cM
• Alliance: Snhg12^tm1.1Chyh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:337694
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding sequence and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of the coding sequence. The neomycin selection cassette was removed via flp-mediated recombination. Snhg12 contains intronic small nucleolar RNAs, Snora16a, Snora44, Snora61 and Snord99, which will also be removed when the floxed region is deleted conditionally. (J:337694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snhg12 Mutation: 10 strains or lines available

References

• Original: J:337694 Li Y, et al., An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity. Cell Rep. 2022 Apr 12;39(2):110656
• All: 1 reference(s)