Phenotypes associated with this allele

• Allele Symbol: Mapre2^tm1.1Dak
• Allele Name: targeted mutation 1.1, David A Keays
• Allele ID: MGI:8325638
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mapre2^tm1.1Dak/Mapre2^tm1.1Dak Tg(Nes-cre)1Atp/0	involves: C57BL/6	MGI:8325747

Genotype
MGI:8325747

cn1

• Allelic Composition: Mapre2^tm1.1Dak/Mapre2^tm1.1Dak; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitosis ( J:382375 )

• more cells in M phase in E14.5 embryonic brain

• higher ratio of cells in (pro)metaphase versus anaphase in E14.5 embryonic brain

• more mitotic cells in prometaphase in E14.5 embryonic brain

• normal mitotic spindle morphology in E14.5 embryonic brain

nervous system

abnormal cerebral cortex morphology ( J:382375 )

• thin cortex at age P0

• fewer neurons in layers II-IV at age P0

• normal cortical lamination

loss of cortex neurons ( J:382375 )

• fewer neurons in layers II-IV at age P0

thin cerebral cortex ( J:382375 )

• at age P0