Phenotypes associated with this allele

• Allele Symbol: Nrip1^em2Xav
• Allele Name: endonuclease-mediated mutation 2, Ramnik J Xavier
• Allele ID: MGI:8325263
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nrip1^em2Xav/Nrip1^em2Xav	involves: C57BL/6	MGI:8325275

Genotype
MGI:8325275

hm1

• Allelic Composition: Nrip1^em2Xav/Nrip1^em2Xav
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:382768 )

• increased number of CD4+ T cells in inflamed intestines of immune-compromised recipient mice that received KO T cells

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:382768 )

• higher proportion of IFNG+ IL17A+ RORC+ CD4+ in lamina propria (LP) of colon and small intestine

• normal levels of total FOXP3+ and RORC+ FOXP3+ regulatory T cells

homeostasis/metabolism

increased interferon-gamma level ( J:382768 )

• in inflamed intestines of immune-compromised recipient mice that received KO T cells

immune system

increased susceptibility to induced colitis ( J:382768 )

• increased number of CD4+ T cells in inflamed intestines of immune-compromised recipient mice that received KO T cells

increased CD4-positive, alpha-beta T cell number ( J:382768 )

• higher proportion of IFNG+ IL17A+ RORC+ CD4+ in lamina propria (LP) of colon and small intestine

• normal levels of total FOXP3+ and RORC+ FOXP3+ regulatory T cells

increased interferon-gamma level ( J:382768 )

• in inflamed intestines of immune-compromised recipient mice that received KO T cells

increased interleukin-17 secretion ( J:382768 )

• in inflamed intestines of immune-compromised recipient mice that received KO T cells