Phenotypes associated with this allele

• Allele Symbol: Cmpk2^em2Wjcn
• Allele Name: endonuclease-mediated mutation 2, Wan-Jin Chen
• Allele ID: MGI:8325050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cmpk2^em2Wjcn/Cmpk2^em2Wjcn	involves: C57BL/6J	MGI:8325054

Genotype
MGI:8325054

hm1

• Allelic Composition: Cmpk2^em2Wjcn/Cmpk2^em2Wjcn
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular ATP level ( J:383086 )

• in brain neurons

decreased neuron mitochondrial DNA content ( J:383086 )

• 25-30% reduction in brain neurons

abnormal mitochondrial crista morphology ( J:383086 )

• reduced cristae coverage in brain neurons

• non-compacted, warped and fragmented in brain neurons

disorganized mitochondrial cristae ( J:383086 )

• in brain neurons

abnormal mitochondrial ATP synthesis coupled electron transport ( J:383086 )

• decreased intracellular ATP levels in brain neurons

• increased intracellular inorganic phosphate levels in brain neurons

homeostasis/metabolism

decreased cellular ATP level ( J:383086 )

• in brain neurons

increased phosphate level ( J:383086 )

• increased intracellular inorganic phosphate levels in brain neurons

nervous system

decreased neuron mitochondrial DNA content ( J:383086 )

• 25-30% reduction in brain neurons

calcified brain ( J:383086 )

• progressive calcification from age 10 months to age 14 months