Phenotypes associated with this allele

• Allele Symbol: 4930447C04Rik^em2Qsh
• Allele Name: endonuclease-mediated mutation 2, Qinghua Shi
• Allele ID: MGI:8323063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4930447C04Rik^em2Qsh/4930447C04Rik^em2Qsh	involves: C57BL/6	MGI:8355283

Genotype
MGI:8355283

hm1

• Allelic Composition: 4930447C04Rik^em2Qsh/4930447C04Rik^em2Qsh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal chromosomal synapsis ( J:383089 )

♂ • in spermatocytes, homologous chromosomes are able to pair but do not synapse because all the known central elements of the synaptonemal complex are missing

♂ • however, zygotene spermatocytes show no change in the average number of REDIC1 (regulator of DNA class I crossover intermediates 1) foci per cell, indicating that REDIC1 localization is independent of synapsis

abnormal male meiosis ( J:383089 )

♂ • although early recombination intermediates marked by MSH4 are formed in spermatocytes, they fail to be processed into late recombination nodules

abnormal synaptonemal complex ( J:383089 )

♂ • all known central elements of the synaptonemal complex are absent

cellular

abnormal chromosomal synapsis ( J:383089 )

♂ • in spermatocytes, homologous chromosomes are able to pair but do not synapse because all the known central elements of the synaptonemal complex are missing

♂ • however, zygotene spermatocytes show no change in the average number of REDIC1 (regulator of DNA class I crossover intermediates 1) foci per cell, indicating that REDIC1 localization is independent of synapsis

abnormal male meiosis ( J:383089 )

♂ • although early recombination intermediates marked by MSH4 are formed in spermatocytes, they fail to be processed into late recombination nodules

abnormal synaptonemal complex ( J:383089 )

♂ • all known central elements of the synaptonemal complex are absent