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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat5aem1Wjl
endonuclease-mediated mutation 1, Warren J Leonard
MGI:8323011
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat5aem1Wjl/Stat5aem1Wjl involves: C57BL/6J * DBA/2J MGI:8323017
cx2
 		Stat5aem1Wjl/Stat5a+
Stat5bem1Wjl/Stat5b+ 		involves: C57BL/6J * DBA/2J MGI:8323020


Genotype
MGI:8323017
hm1
Allelic
Composition		 Stat5aem1Wjl/Stat5aem1Wjl
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5aem1Wjl mutation (0 available); any Stat5a mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:353834 )
• more CD8+ T cells in G0/G1 phase and fewer in S phase after stimulation with IL2
decreased T cell proliferation ( J:353834 )
• reduced cellularity after stimulation with IL2
decreased mammary gland epithelial cell proliferation ( J:353834 )
• failure to expand ductal epithelium in late pregnancy

endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:353834 )
• failure to expand ductal epithelium in late pregnancy
abnormal mammary gland duct morphology ( J:353834 )
• failure to expand ductal epithelium in late pregnancy

growth/size/body
growth/size/body region phenotype ( J:353834 )
N
• normal body weight

hematopoietic system
decreased T cell proliferation ( J:353834 )
• reduced cellularity after stimulation with IL2

immune system
decreased T cell proliferation ( J:353834 )
• reduced cellularity after stimulation with IL2

integument
decreased mammary gland epithelial cell proliferation ( J:353834 )
• failure to expand ductal epithelium in late pregnancy
abnormal mammary gland duct morphology ( J:353834 )
• failure to expand ductal epithelium in late pregnancy

mortality/aging
mortality/aging ( J:353834 )
N
• viable

reproductive system




Genotype
MGI:8323020
cx2
Allelic
Composition		 Stat5aem1Wjl/Stat5a+
Stat5bem1Wjl/Stat5b+
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5aem1Wjl mutation (0 available); any Stat5a mutation (50 available)
Stat5bem1Wjl mutation (0 available); any Stat5b mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nursing ( J:353834 )
• pups die, owing to dehydration and starvation

embryo

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:353834 )
N
• normal thymocyte numbers

growth/size/body
decreased embryo size ( J:353834 )

hematopoietic system
anemia ( J:353834 )
• pale embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/05/2026
MGI 6.24 		The Jackson Laboratory