Phenotypes associated with this allele

• Allele Symbol: Zranb1^em1Htran
• Allele Name: endonuclease-mediated mutation 1, Hoanh Tran
• Allele ID: MGI:8322630
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zranb1^em1Htran/Zranb1^em1Htran	C57BL/6J-Zranb1^em1Htran	MGI:8322641

Genotype
MGI:8322641

hm1

• Allelic Composition: Zranb1^em1Htran/Zranb1^em1Htran
• Genetic Background: C57BL/6J-Zranb1^em1Htran

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:353987 )

• reduced latency to fall in rotarod test

cellular

decreased oligodendrocyte number ( J:353987 )

• in fore- and midbrain

embryo

embryo phenotype ( J:353987 )

N • mice born at normal Mendelian ratios

growth/size/body

decreased body weight ( J:353987 )

• ~15% lower weight

mortality/aging

mortality/aging ( J:353987 )

N • viable

nervous system

nervous system phenotype ( J:353987 )

N • normal structure and lamination

decreased oligodendrocyte number ( J:353987 )

• in fore- and midbrain

abnormal medium spiny neuron morphology ( J:353987 )

• fewer spiny neurons in striatum

decreased dopaminergic neuron number ( J:353987 )

• in substantia nigra pars compacta

• reduced number of axons projecting into striatum, motor cortex and claustrum

reproductive system

reproductive system phenotype ( J:353987 )

N • fertile