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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ubn1em1Awu
endonuclease-mediated mutation 1, Anton Wutz
MGI:8319101
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ubn1em1Awu/Ubn1em1Awu C57BL/6J-Ubn1em1Awu MGI:8331917
cx2
 		Ubn1em1Awu/Ubn1em1Awu
Ubn2em1Awu/Ubn2em1Awu 		C57BL/6J-Ubn2em1Awu Ubn1em1Awu MGI:8331923


Genotype
MGI:8331917
hm1
Allelic
Composition		 Ubn1em1Awu/Ubn1em1Awu
Genetic
Background		 C57BL/6J-Ubn1em1Awu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubn1em1Awu mutation (0 available); any Ubn1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:368155 )
• mice of both sexes are viable and fertile and show normal litter sizes, a balanced sex ratio, and no overt phenotypes relative to wild-type controls




Genotype
MGI:8331923
cx2
Allelic
Composition		 Ubn1em1Awu/Ubn1em1Awu
Ubn2em1Awu/Ubn2em1Awu
Genetic
Background		 C57BL/6J-Ubn2em1Awu Ubn1em1Awu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubn1em1Awu mutation (0 available); any Ubn1 mutation (44 available)
Ubn2em1Awu mutation (0 available); any Ubn2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:368155 )
• no double homozygous mice are obtained, suggesting embryonic lethality with complete penetrance
• crosses of heterozygous Ubn2em1Awu mice with homozygous Ubn1em1Awu mice result in a severely skewed sex ratio, with a 2-fold reduction in the recovery of female double homozygous embryos relative to male double homozygotes at E10.5

growth/size/body
embryonic growth retardation ( J:368155 )
• crosses of heterozygous Ubn2em1Awu mice with homozygous Ubn1em1Awu mice yield several double homozygous embryos that show highly variable developmental delay at E10.5

embryo
failure of initiation of embryo turning ( J:368155 )
• none of the double homozygous embryos have initiated turning at E10.5
embryonic growth arrest ( J:368155 )
• several double homozygous embryos show developmental arrest before turning
embryonic growth retardation ( J:368155 )
• crosses of heterozygous Ubn2em1Awu mice with homozygous Ubn1em1Awu mice yield several double homozygous embryos that show highly variable developmental delay at E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/05/2026
MGI 6.24 		The Jackson Laboratory