Ubn1^em1Awu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ubn1^em1Awu
• Name: ubinuclein 1; endonuclease-mediated mutation 1, Anton Wutz
• MGI ID: MGI:8319101
• Synonyms: Ubn1^-
• Gene: Ubn1 Location: Chr16:4867921-4904153 bp, + strand Genetic Position: Chr16, 2.49 cM
• Alliance: Ubn1^em1Awu page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR genome editing technology generated an approximately 10 kb deletion spanning exons 3-7, encoding the N-terminal NHRD and HRD domains (also encompassing the HUN domain), which are required for interaction with HIRA and histone H3.3. Western analysis confirmed the absence of protein in liver nuclear extracts. (J:368155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubn1 Mutation: 44 strains or lines available

References

• Original: J:368155 Monfort A, et al., Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation. PLoS Genet. 2025 Jun;21(6):e1011711
• All: 1 reference(s)