Phenotypes associated with this allele

• Allele Symbol: Plcxd2^tm1.1Jdw
• Allele Name: targeted mutation 1.1, Joris de Wit
• Allele ID: MGI:8318986
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw Rorb^tm1.1(cre)Hze/Rorb^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl	MGI:8324948
cn2	Gpr158^tm1.1Jdw/Gpr158^tm1.1Jdw Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw	involves: C57BL/6	MGI:8324973

Genotype
MGI:8324948

cn1

• Allelic Composition: Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw; Rorb^{tm1.1(cre)Hze}/Rorb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendritic spine morphology ( J:372545 )

• dendritic spines of neurons shift toward a more mature phenotype, with a decrease in immature filopodia-type protrusions and a concomitant increase in mature mushroom-type spines indicating promotion of dendritic spine maturation

• neurons from mice injected with adenoviruses expressing TRE-DIO-FLPo and TRE-fDIO-tdTomato-IRES-tTA into the barrel cortex at P0 exhibit more spine apparatus-containing dendritic spines

• however, dendritic spine density is unaffected

Genotype
MGI:8324973

cn2

• Allelic Composition: Gpr158^tm1.1Jdw/Gpr158^tm1.1Jdw; Plcxd2^tm1.1Jdw/Plcxd2^tm1.1Jdw
• Genetic Background: involves: C57BL/6

nervous system

nervous system phenotype ( J:372545 )

N • mice injected with adenoviruses (AAV) expressing TRE-cre and SYN-DIO-GFP-IRES-tTA in the barrel cortex to induce expression of cre and GFP in L4 cortical neurons show rescue of the loss of mature mushroom-type spines and increase in immature filopodia-type protrusions in Gpr158 conditional knock-out neurons and show rescue of the spine apparatus content of dendritic spines to that seen in wild-type mice