Phenotypes associated with this allele

• Allele Symbol: CK137956^em1Xjg
• Allele Name: endonuclease-mediated mutation 1, Xuejiang Guo
• Allele ID: MGI:8316940
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	CK137956^em1Xjg/CK137956^em1Xjg	C57BL/6J-CK137956^em1Xjg	MGI:8316942

Genotype
MGI:8316942

hm1

• Allelic Composition: CK137956^em1Xjg/CK137956^em1Xjg
• Genetic Background: C57BL/6J-CK137956^em1Xjg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:345318 )

♂ • sperm are absent in the caput and cauda epididymis and the epididymis is filled with round cells

♂ • testes lack elongated spermatids and sperm, and contain syncytium with multiple nuclei of round spermatids

increased testis apoptosis ( J:345318 )

• percentage of apoptotic cells in seminiferous tubules and the average number of apoptotic cells per tubule are increased

decreased testis weight ( J:345318 )

♂ • males exhibit reduced testis weight, while body weight is unaffected

arrest of spermiogenesis ( J:345318 )

♂ • round spermatids arrest at step 6 with acrosome angles of 95-120 degrees

♂ • however, meiotic progression of spermatocytes is not affected

male infertility ( J:345318 )

♂ • males produce no offspring

endocrine/exocrine glands

increased testis apoptosis ( J:345318 )

• percentage of apoptotic cells in seminiferous tubules and the average number of apoptotic cells per tubule are increased

decreased testis weight ( J:345318 )

♂ • males exhibit reduced testis weight, while body weight is unaffected

cellular

azoospermia ( J:345318 )

♂ • sperm are absent in the caput and cauda epididymis and the epididymis is filled with round cells

♂ • testes lack elongated spermatids and sperm, and contain syncytium with multiple nuclei of round spermatids

increased testis apoptosis ( J:345318 )

• percentage of apoptotic cells in seminiferous tubules and the average number of apoptotic cells per tubule are increased