CK137956^em1Xjg
Endonuclease-mediated Allele Detail

Summary

• Symbol: CK137956^em1Xjg
• Name: cDNA sequence CK137956; endonuclease-mediated mutation 1, Xuejiang Guo
• MGI ID: MGI:8316940
• Synonyms: Tssa^-
• Gene: CK137956 Location: Chr4:127821385-127864744 bp, - strand Genetic Position: Chr4, 61.65 cM
• Alliance: CK137956^em1Xjg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated an 8 bp deletion (AAGAAGCC) in exon 3. Western blot analysis confirmed the absence of protein in testis. (J:345318)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any CK137956 Mutation: 22 strains or lines available

References

• Original: J:345318 Chen Y, et al., Regulation of Miwi-mediated mRNA stabilization by Ck137956/Tssa is essential for male fertility. BMC Biol. 2023 Apr 17;21(1):89
• All: 1 reference(s)