Phenotypes associated with this allele

• Allele Symbol: Clmb^em1Hsul
• Allele Name: endonuclease-mediated mutation 1, Hei Sook Sul
• Allele ID: MGI:8310114
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Clmb^em1Hsul/Clmb^em1Hsul Tg(Ucp1-cre)1Evdr/0	involves: C57BL/6J * FVB	MGI:8312153

Genotype
MGI:8312153

cn1

• Allelic Composition: Clmb^em1Hsul/Clmb^em1Hsul; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body fat mass ( J:374728 )

• mice show increased fat mass without changes in lean mass

increased body weight ( J:374728 )

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:374728 )

• mice exposed to acute cold at 4 degrees Celsius are less cold-intolerant compared to controls after 5 hours of cold exposure

decreased oxygen consumption ( J:374728 )

• mice exhibit lower oxygen consumption rate at all temperatures at night and even greater oxygen consumption rate reduction at 4 degrees Celsius

• however, food intake and locomotor activity are unchanged

impaired glucose tolerance ( J:374728 )

• mice fed a high-fat diet exhibit higher blood glucose levels during glucose tolerance test than wild-type mice

insulin resistance ( J:374728 )

• mice fed a high-fat diet exhibit impaired insulin sensitivity

adipose tissue

increased body fat mass ( J:374728 )

• mice show increased fat mass without changes in lean mass

abnormal brown adipose tissue physiology ( J:374728 )

• brown adipose tissue shows lower oxygen consumption rate, indicating that brown adipose tissue contributes to changes in whole-body energy expenditure

abnormal brown adipose tissue thermogenesis ( J:374728 )

• brown adipose tissue shows lower temperature than in controls upon 6 hours of cold exposure indicating impaired thermogenic capacity