Phenotypes associated with this allele

• Allele Symbol: Dnah3^em1Wbhe
• Allele Name: endonuclease-mediated mutation 1, Wen-Bin He
• Allele ID: MGI:8297882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnah3^em1Wbhe/Dnah3^em1Wbhe	involves: C57BL/6	MGI:8297884

Genotype
MGI:8297884

hm1

• Allelic Composition: Dnah3^em1Wbhe/Dnah3^em1Wbhe
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:376129 )

♂ • sperm tails show curved and irregular morphology

♂ • sperm flagella show partially absent inner dynein arms but have the typical 9+2 axonemal structure and peri-axonemal structures

decreased sperm progressive motility ( J:376129 )

♂

asthenozoospermia ( J:376129 )

♂ • sperm motility, progressive motility, and swimming velocity are lower than in wild-type sperm

male infertility ( J:376129 )

♂ • males are completely infertile

♂ • however, no differences in testicular size or testis/body weight ratio are seen and presence of spermatogenic cells are seen at different stages in the testes

♂ • intracytoplasmic sperm injection of mutant spermatozoa into wild-type oocytes shows similar rates of two-cell embryos and blastocysts

cellular

cellular phenotype ( J:376129 )

♂N • gross ciliary morphology of trachea and brain appear normal

abnormal sperm flagellum morphology ( J:376129 )

♂ • sperm tails show curved and irregular morphology

♂ • sperm flagella show partially absent inner dynein arms but have the typical 9+2 axonemal structure and peri-axonemal structures

decreased sperm progressive motility ( J:376129 )

♂

asthenozoospermia ( J:376129 )

♂ • sperm motility, progressive motility, and swimming velocity are lower than in wild-type sperm