Dnah3^em1Wbhe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnah3^em1Wbhe
• Name: dynein, axonemal, heavy chain 3; endonuclease-mediated mutation 1, Wen-Bin He
• MGI ID: MGI:8297882
• Synonyms: Dnah3^ko1
• Gene: Dnah3 Location: Chr7:119521894-119694503 bp, - strand Genetic Position: Chr7, 64.34 cM
• Alliance: Dnah3^em1Wbhe page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology targeting exon 35 generated a frameshift mutation by inserting a T base (c.5039_5040insT; p.M1680I fs*9). Western blot analysis confirmed the absence of protein in the testes. (J:376129)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnah3 Mutation: 185 strains or lines available

References

• Original: J:376129 Meng GQ, et al., Bi-allelic variants in DNAH3 cause male infertility with asthenoteratozoospermia in humans and mice. Hum Reprod Open. 2024;2024(1):hoae003
• All: 1 reference(s)