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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmxl1em2Rstot
endonuclease-mediated mutation 2, Rolf Stottmann
MGI:8293347
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dmxl1em2Rstot/Dmxl1em2Rstot involves: C57BL/6J * C57BL/6NCrl MGI:8296191
ht2
 		Dmxl1em2Rstot/Dmxl1+ involves: C57BL/6J * C57BL/6NCrl MGI:8296192
ht3
 		Dmxl1em2Rstot/Dmxl1em3Rstot involves: C57BL/6J * C57BL/6NCrl MGI:8296195
ht4
 		Dmxl1em1Rstot/Dmxl1em2Rstot involves: C57BL/6J * C57BL/6NCrl MGI:8296196


Genotype
MGI:8296191
hm1
Allelic
Composition		 Dmxl1em2Rstot/Dmxl1em2Rstot
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmxl1em2Rstot mutation (0 available); any Dmxl1 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:376266 )
• homozygotes are recovered in near Mendelian ratios at E13.5 and E18.5 with no gross morphological abnormalities; mandibular length (normalized to body weight) is not significantly altered at E18.5




Genotype
MGI:8296192
ht2
Allelic
Composition		 Dmxl1em2Rstot/Dmxl1+
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmxl1em2Rstot mutation (0 available); any Dmxl1 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:376266 )
• mice are viable and fertile and show normal mandibular length (normalized to body weight) at E18.5




Genotype
MGI:8296195
ht3
Allelic
Composition		 Dmxl1em2Rstot/Dmxl1em3Rstot
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmxl1em2Rstot mutation (0 available); any Dmxl1 mutation (159 available)
Dmxl1em3Rstot mutation (0 available); any Dmxl1 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:376266 )
• mice are viable, exhibit no gross phenotypes at E18.5 or P14, and have a body mass comparable to that in wild-type and single heterozygous controls at P21; mandibular length (normalized to body weight) is not significantly altered at E18.5 or reduced at P21 and P90




Genotype
MGI:8296196
ht4
Allelic
Composition		 Dmxl1em1Rstot/Dmxl1em2Rstot
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmxl1em1Rstot mutation (0 available); any Dmxl1 mutation (159 available)
Dmxl1em2Rstot mutation (0 available); any Dmxl1 mutation (159 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:376266 )
• mice are recovered in near Mendelian ratios at P14 with no apparent gross morphological abnormalities and survive normally as adults




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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory