Phenotypes associated with this allele

• Allele Symbol: Rab10^em1Bosu
• Allele Name: endonuclease-mediated mutation 1, Bo Su
• Allele ID: MGI:8288690
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab10^em1Bosu/Rab10^em1Bosu	C57BL/6J-Rab10^em1Bosu	MGI:8288694

Genotype
MGI:8288694

hm1

• Allelic Composition: Rab10^em1Bosu/Rab10^em1Bosu
• Genetic Background: C57BL/6J-Rab10^em1Bosu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:378281 )

N • normal behavior in Y, T and Barnes maze tests and in fear conditioning test

N • normal behavior in tail suspension and forced swimming tests

N • normal behavior in accelerating rotarod test

abnormal behavior ( J:378281 )

• buried fewer marbles in marble burying test

• shredded fewer nestlets in nestlet shredding test

increased thigmotaxis ( J:378281 )

• less time spent in center in open field test

• normal total locomotor activity in open field test

• less time spent in open arms or sections in elevated plus maze and zero maze

• less time spent in light chamber in light/dark exploration test

nervous system

nervous system phenotype ( J:378281 )

N • normal brain weight

N • normal excitatory miniature inhibitory postsynaptic currents in striatum

N • normal postsynaptic density and synaptic vesicle density and diameter in striatum

N • normal neuronal density in striatum, hippocampus and cortex

abnormal medium spiny neuron morphology ( J:378281 )

• increased neurite number and dendritic length in MSNs in striatum

abnormal neurite morphology ( J:378281 )

• increased neurite number and dendritic length in medium spiny neurons (MSNs) in striatum

abnormal dendrite morphology ( J:378281 )

• increased dendritic length in medium spiny neurons (MSNs) in striatum

• normal spine density in medium spiny neurons (MSNs) in striatum

abnormal dendrite arborization pattern ( J:378281 )

• increased total number of crossings in medium spiny neurons (MSNs) in striatum

• normal in amygdala and CA1 neurons in hippocampus

abnormal dendritic spine morphology ( J:378281 )

• normal in amygdala and CA1 neurons in hippocampus

• increased prevalence of mature (stubby, mushroom, branched) spines in medium spiny neurons (MSNs) in striatum

abnormal dendritic mushroom spine morphology ( J:378281 )

• normal in amygdala and CA1 neurons in hippocampus

• increased prevalence in medium spiny neurons (MSNs) in striatum

abnormal dendritic stubby spine morphology ( J:378281 )

• normal in amygdala and CA1 neurons in hippocampus

• increased prevalence in medium spiny neurons (MSNs) in striatum

abnormal dendritic thin spine morphology ( J:378281 )

• normal in amygdala and CA1 neurons in hippocampus

• reduced prevalence in medium spiny neurons (MSNs) in striatum

abnormal miniature inhibitory postsynaptic currents ( J:378281 )

• reduced frequency in striatum

• normal amplitude in striatum

decreased miniature inhibitory postsynaptic current frequency ( J:378281 )

• in striatum

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:378281 )

N • normal O2 consumption, CO2 production, respiratory quotient, and heat production

growth/size/body

growth/size/body region phenotype ( J:378281 )

N • normal body weight