Phenotypes associated with this allele

• Allele Symbol: Tg(ATP6*)#aJguy
• Allele Name: transgene insertion #a, John Guy
• Allele ID: MGI:8286375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(ATP6*)#aJguy	B6;D2-Tg(ATP6*)#aJguy/Jguy	MGI:8286421

Genotype
MGI:8286421

tg1

• Allelic Composition: Tg(ATP6*)#aJguy
• Genetic Background: B6;D2-Tg(ATP6*)#aJguy/Jguy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:378510 )

hunched posture ( J:378510 )

• earliest observation 10 weeks of age

paralysis ( J:378510 )

• earliest observation 14 weeks of age

seizures ( J:378510 )

mortality/aging

premature death ( J:378510 )

• 20% of the expressing population died before 6 months of age

growth/size/body

weight loss ( J:378510 )

neoplasm

increased tumor incidence ( J:378510 )

nervous system

seizures ( J:378510 )

retina photoreceptor degeneration ( J:378510 )

spongiform encephalopathy ( J:378510 )

vision/eye

retina photoreceptor degeneration ( J:378510 )

thin retina inner nuclear layer ( J:378510 )

retina outer nuclear layer degeneration ( J:378510 )

abnormal electroretinogram waveform feature ( J:378510 )

• declines in flash electroretinogram and pattern electroretinogram

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Leigh disease		DOID:3652	OMIM:256000	J:378510