Phenotypes associated with this allele

• Allele Symbol: C2cd4a^tm1Dac
• Allele Name: targeted mutation 1, Domenico Accili
• Allele ID: MGI:8286328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	C2cd4a^tm1Dac/C2cd4a^tm1Dac Tg(Ins2-cre)23Herr/0	Not Specified	MGI:8286329

Genotype
MGI:8286329

cn1

• Allelic Composition: C2cd4a^tm1Dac/C2cd4a^tm1Dac; Tg(Ins2-cre)23Herr/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:334129 )

• islets show an approximate 50% reduction in glucose-stimulated insulin secretion

• mice show an approximate 35% decrease in insulin secretary capacity during hyperglycemic clamps

decreased circulating insulin level ( J:334129 )

• 12-week-old mice fed a normal diet display reduced insulin levels in the fed state

impaired glucose tolerance ( J:334129 )

• 12-week-old mice fed a normal diet are glucose intolerant

endocrine/exocrine glands

decreased insulin secretion ( J:334129 )

• islets show an approximate 50% reduction in glucose-stimulated insulin secretion

• mice show an approximate 35% decrease in insulin secretary capacity during hyperglycemic clamps

growth/size/body

growth/size/body region phenotype ( J:334129 )

N • 12-week-old mice fed a normal diet show normal weight