C2cd4a^tm1Dac
Targeted Allele Detail

Summary

• Symbol: C2cd4a^tm1Dac
• Name: C2 calcium-dependent domain containing 4A; targeted mutation 1, Domenico Accili
• MGI ID: MGI:8286328
• Gene: C2cd4a Location: Chr9:67737814-67739612 bp, - strand Genetic Position: Chr9, 36.77 cM
• Alliance: C2cd4a^tm1Dac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334129
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the first intron and a second loxP site was inserted 200-bp downstream of the polyA tail. (J:334129)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C2cd4a Mutation: 9 strains or lines available

References

• Original: J:334129 Kuo T, et al., Identification of C2CD4A as a human diabetes susceptibility gene with a role in beta cell insulin secretion. Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20033-20042
• All: 1 reference(s)