Phenotypes associated with this allele

• Allele Symbol: Rragc^em2Efe
• Allele Name: endonuclease-mediated mutation 2, Alejo Efeyan
• Allele ID: MGI:8283456
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rragc^em2Efe/Rragc^em2Efe	Not Specified	MGI:8286191
ht2	Rragc^em2Efe/Rragc^+	Not Specified	MGI:8286189

Genotype
MGI:8286191

hm1

• Allelic Composition: Rragc^em2Efe/Rragc^em2Efe
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:356252 )

• no pups born

Genotype
MGI:8286189

ht2

• Allelic Composition: Rragc^em2Efe/Rragc⁺
• Genetic Background: Not Specified

endocrine/exocrine glands

pancreas inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

hematopoietic system

decreased lymphocyte cell number ( J:356252 )

• decreased numbers of mature lymphoid cells at age 18 months

decreased B cell number ( J:356252 )

• in peripheral blood at age 18 months

increased myeloid cell number ( J:356252 )

• increased numbers of mature myeloid cells at age 18 months

homeostasis/metabolism

increased circulating creatinine level ( J:356252 )

• at age 18 months

increased circulating amylase level ( J:356252 )

• at age 18 months

increased cytokine level ( J:356252 )

• in peripheral blood at age 18 months

immune system

pancreas inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

decreased lymphocyte cell number ( J:356252 )

• decreased numbers of mature lymphoid cells at age 18 months

decreased B cell number ( J:356252 )

• in peripheral blood at age 18 months

increased cytokine level ( J:356252 )

• in peripheral blood at age 18 months

liver inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

kidney inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

lung inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

liver/biliary system

liver inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

mortality/aging

premature death ( J:356252 )

• premature age-related decline at age 16 months

neoplasm

decreased organ/body region tumor incidence ( J:356252 )

renal/urinary system

kidney inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months

respiratory system

lung inflammation ( J:356252 )

• scattered foci of inflammation at age 18 months