Rragc^em2Efe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rragc^em2Efe
• Name: Ras-related GTP binding C; endonuclease-mediated mutation 2, Alejo Efeyan
• MGI ID: MGI:8283456
• Synonyms: Rragc^mut, Rragc^S74N
• Gene: Rragc Location: Chr4:123811239-123830790 bp, + strand Genetic Position: Chr4, 57.42 cM, cytoband D
• Alliance: Rragc^em2Efe page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Constitutively active)
• Mutation: Nucleotide substitutions
• Mutation details: Serine codon 74 (TCC) in exon 1 was changed to asparagine (AAC) (p.S74N) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation renders the encoded protein constitutively active. (J:356252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rragc Mutation: 16 strains or lines available

References

• Original: J:356252 Ortega-Molina A, et al., A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan. Nat Aging. 2024 Aug;4(8):1102-1120
• All: 1 reference(s)