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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Efcab5em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:8280444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Efcab5em1Osb/Efcab5em1Osb involves: C57BL/6NCrSlc * DBA/2CrSlc MGI:8280755


Genotype
MGI:8280755
hm1
Allelic
Composition		 Efcab5em1Osb/Efcab5em1Osb
Genetic
Background		 involves: C57BL/6NCrSlc * DBA/2CrSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efcab5em1Osb mutation (0 available); any Efcab5 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm motility ( J:377938 )
• decrease in the percentage of motile spermatozoa after 10 min and 120 min of incubation in capacitation medium
• curvilinear velocity, straight line velocity, and average path velocity are decreased after 10 min of incubation and straight line velocity and average path velocity are decreased after 120 min of incubation
abnormal flagellar waveform ( J:377938 )
• the increase in maximal bending angles of flagella relative to sperm heads (alpha-angle) that is seen after 2 hours of incubation in capacitation medium is not seen, indicating abnormal flagellar motility patterns
decreased sperm progressive motility ( J:377938 )
• decrease in the percentage of progressive spermatozoa after 10 min and 120 min of incubation in capacitation medium
reduced male fertility ( J:377938 )
• males show slightly decreased fertility
• however, no apparent anomalies in morphology of the male reproductive organs are seen

cellular
abnormal sperm motility ( J:377938 )
• decrease in the percentage of motile spermatozoa after 10 min and 120 min of incubation in capacitation medium
• curvilinear velocity, straight line velocity, and average path velocity are decreased after 10 min of incubation and straight line velocity and average path velocity are decreased after 120 min of incubation
abnormal flagellar waveform ( J:377938 )
• the increase in maximal bending angles of flagella relative to sperm heads (alpha-angle) that is seen after 2 hours of incubation in capacitation medium is not seen, indicating abnormal flagellar motility patterns
decreased sperm progressive motility ( J:377938 )
• decrease in the percentage of progressive spermatozoa after 10 min and 120 min of incubation in capacitation medium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory