Analysis Tools
behavior/neurological
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• 3-fold longer latency in negative geotaxis test at age P11
• shorter latency to fall in rotarod test at age P90
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• 5-20-fold increase in USVs emitted after separation from mother at ages P4-P9
• increase in complex multicomponent calls and decrease in simple calls after separation from mother at ages P4-P9
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cellular
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• 7-fold increase in abnormal mitochondria and 3-fold increase in number of mitophagosomes in brain at age P11
• normal total number of mitochondria in brain at age P11
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• at age P11
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growth/size/body
| N |
• normal body weight at age P11
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microcephaly
(
J:359113
)
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• at age P30
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muscle
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• shorter latency to fall in forelimb suspension test at age P11
• normal latency to fall in hindlimb suspension test at age P11
• normal grip strength at age P11
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nervous system
| N |
• normal symmetric synapse number in ventral leaf of dentate gyrus at age P11
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• 7-fold increase in abnormal mitochondria and 3-fold increase in number of mitophagosomes in brain at age P11
• normal total number of mitochondria in brain at age P11
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• at age P11
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• regionally reduced brain volume at age 4 weeks
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• at age P11
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• at age P30
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• at age 4 weeks
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• thinner at age 4 weeks
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• reduced area of presynaptic bouton of asymmetric and symmetric synapses in ventral leaf of dentate gyrus at age P11
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• increased number in ventral leaf of dentate gyrus at age P11
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• reduced postsynaptic density area in ventral leaf of dentate gyrus at age P11
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• in hippocampus at age P11
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• at age P11
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