Phenotypes associated with this allele

• Allele Symbol: Fkbp9^tm1.1Xdz
• Allele Name: targeted mutation 1.1, Xu-Dong Zhao
• Allele ID: MGI:8278887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fkbp9^tm1.1Xdz/Fkbp9^tm1.1Xdz	Not Specified	MGI:8326145

Genotype
MGI:8326145

cn1

• Allelic Composition: Fkbp9^tm1.1Xdz/Fkbp9^tm1.1Xdz
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased tumor-free survival time ( J:357743 )

• mice injected with a lentivirus that expresses oncogenic ras and shRNA against the tumor suppressor Tp53 (RAS-V12-IRES-Cre-ER-shp53) lentivirus into the hippocampus to induce glioblastoma and treated with tamoxifen to delete Fkbp9 in infected cells show prolonged survival than wild-type controls

neoplasm

increased tumor cell death ( J:357743 )

• tumors from mice injected with a RAS-V12-IRES-Cre-ER-shp53 lentivirus into the hippocampus to induce glioblastoma and treated with tamoxifen to delete Fkbp9 show an increase in Chop expression and activated cleaved-caspase3 indicating induction of ER stress-induced Chop-related apoptosis in tumor cells

decreased tumor cell proliferation ( J:357743 )

• mice injected with a RAS-V12-IRES-Cre-ER-shp53 lentivirus into the hippocampus to induce glioblastoma and treated with tamoxifen to delete Fkbp9 in infected cells show reduced proliferation rate of the induced tumors

decreased incidence of induced tumors ( J:357743 )

• mice injected with a lentivirus that expresses oncogenic ras and shRNA against the tumor suppressor Tp53 (RAS-V12-IRES-Cre-ER-shp53) lentivirus into the hippocampus to induce intracranial glioblastoma and treated with tamoxifen to delete Fkbp9 in infected cells show less neoplastic tissue than in wild-type mice