Phenotypes associated with this allele

• Allele Symbol: Emcn^tm1.2Pdmr
• Allele Name: targeted mutation 1.2, Patricia D'Amore
• Allele ID: MGI:8278585
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emcn^tm1.2Pdmr/Emcn^tm1.2Pdmr	involves: C57BL/6	MGI:8278586

Genotype
MGI:8278586

hm1

• Allelic Composition: Emcn^tm1.2Pdmr/Emcn^tm1.2Pdmr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

albuminuria ( J:366307 )

• urinary albumin levels are increased

• however, no changes in urine creatinine concentration are seen

abnormal glomerular capsule space morphology ( J:366307 )

• an increase in albumin is seen in the Bowmans space

abnormal podocyte foot process morphology ( J:366307 )

• decrease in foot process length

fused podocyte foot processes ( J:366307 )

podocyte foot process effacement ( J:366307 )

increased renal glomerulus basement membrane thickness ( J:366307 )

abnormal renal glomerulus morphology ( J:366307 )

• kidneys exhibit smaller glomeruli, increased collagen deposition per glomeruli area, and thickened glomerular endothelial cells

• glomeruli exhibit increased infiltration of CD45+ cells, with an increased proportion of Ly6C^high Ly6G^low myeloid cells

• however, percentages of neutrophils, T lymphocytes, B lymphocytes and endothelial cells in the kidney are unchanged

abnormal glomerular endothelium fenestra morphology ( J:366307 )

• kidneys exhibit disorganized endothelial fenestrations

abnormal glomerular filtration barrier morphology ( J:366307 )

• ultrastructure of the glomerular filtration barrier is disrupted in the kidneys

• kidneys exhibit disorganized fenestrations, regionally thickened basement membrane, and podocyte food process that are affected and fused which together exhibit a defective glomerular filtration barrier

• aged mice (21-24 months) show more severe changes in the glomerular filtration barrier, specifically in basement membrane thickening and podocyte foot process fusion and effacement, suggesting progressive degeneration of the glomerular filtration barrier

abnormal glomerular filtration barrier function ( J:366307 )

• mice exhibit impaired glomerular barrier function

homeostasis/metabolism

albuminuria ( J:366307 )

• urinary albumin levels are increased

• however, no changes in urine creatinine concentration are seen

cardiovascular system

cardiovascular system phenotype ( J:366307 )

N • no differences in systolic or average arterial blood pressure are seen

abnormal glomerular endothelium fenestra morphology ( J:366307 )

• kidneys exhibit disorganized endothelial fenestrations