About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smim26em1Lenh
endonuclease-mediated mutation 1, Lena Ho
MGI:8278444
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smim26em1Lenh/Smim26em1Lenh C57BL/6J-Smim26em1Lenh MGI:8278446


Genotype
MGI:8278446
hm1
Allelic
Composition		 Smim26em1Lenh/Smim26em1Lenh
Genetic
Background		 C57BL/6J-Smim26em1Lenh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smim26em1Lenh mutation (0 available); any Smim26 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:375177 )
• embryonic lethal, with lethality likely occurring between E9.5 and E10.5

growth/size/body
embryonic growth retardation ( J:375177 )
• E9.5 embryos display developmental delays, but E8.5 embryos appear normal
• embryos are severely underdeveloped at E10.5

embryo
embryonic growth retardation ( J:375177 )
• E9.5 embryos display developmental delays, but E8.5 embryos appear normal
• embryos are severely underdeveloped at E10.5

cardiovascular system
abnormal cardiovascular development ( J:375177 )
• embryos lack a circulatory system at E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory