Phenotypes associated with this allele

• Allele Symbol: Htr2c^em1Yonxu
• Allele Name: endonuclease-mediated mutation 1, Yong Xu
• Allele ID: MGI:8278435
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Htr2c^em1Yonxu/Htr2c^+	C57BL/6J-Htr2c^em1Yonxu	MGI:8278527
ot2	Htr2c^em1Yonxu/Y	C57BL/6J-Htr2c^em1Yonxu	MGI:8278526

Genotype
MGI:8278527

ht1

• Allelic Composition: Htr2c^em1Yonxu/Htr2c⁺
• Genetic Background: C57BL/6J-Htr2c^em1Yonxu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:376997 )

N • normal swimming speed in radial arm water maze test

N • normal behavior in response to contextual and cued conditioning

N • normal pain threshold in hot plate test

abnormal short-term spatial reference memory ( J:376997 )

• increased latency in finding the platform in radial arm water maze test 30 min. after training session

Genotype
MGI:8278526

ot2

• Allelic Composition: Htr2c^em1Yonxu/Y
• Genetic Background: C57BL/6J-Htr2c^em1Yonxu

behavior/neurological

behavior/neurological phenotype ( J:376997 )

♂N • normal swimming speed in radial arm water maze test

♂N • normal behavior in response to contextual cued conditioning

♂N • normal pain threshold in hot plate test

impaired cued conditioning behavior ( J:376997 )

♂ • reduced freezing behavior in response to tone cues conditioned with foot shocks

abnormal short-term spatial reference memory ( J:376997 )

♂ • increased latency in finding the platform in radial arm water maze test 30 min. after training session

nervous system

reduced long-term potentiation ( J:376997 )

♂ • blunted LTP in hippocampal ventral CA1 (vCA1) neurons

♂ • normal LTP in hippocampal dorsal CA1 neurons