Phenotypes associated with this allele

• Allele Symbol: Dnajc12^em1.1Mjfa
• Allele Name: endonuclease-mediated mutation 1, Matthew J Farrer
• Allele ID: MGI:8277166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnajc12^em1.1Mjfa/Dnajc12^em1.1Mjfa	involves: C57BL/6J	MGI:8277169

Genotype
MGI:8277169

hm1

• Allelic Composition: Dnajc12^em1.1Mjfa/Dnajc12^em1.1Mjfa
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:376259 )

• decrease in ambulatory distance, ambulatory time, number of rears, and average speed and increase in rest time in an open field assay

nervous system

nervous system phenotype ( J:376259 )

N • no change in dopaminergic synaptic density in the striatum

decreased nervous system dopamine level ( J:376259 )

• in the striatum

abnormal nervous system electrophysiology ( J:376259 )

• in striatal slices electrically evoked dopamine peak response is reduced

abnormal neuron physiology ( J:376259 )

• expression analysis in the striatum indicate major changes in axonal endocytosis and synaptic vesicle recycling

homeostasis/metabolism

decreased circulating phenylalanine level ( J:376259 )

• decreased plasma levels

• however, levels of Tyr and Trp are unchanged

decreased nervous system dopamine level ( J:376259 )

• in the striatum

decreased serotonin level ( J:376259 )

• in the striatum