Dnajc12^em1.1Mjfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnajc12^em1.1Mjfa
• Name: DnaJ heat shock protein family (Hsp40) member C12; endonuclease-mediated mutation 1, Matthew J Farrer
• MGI ID: MGI:8277166
• Gene: Dnajc12 Location: Chr10:63218222-63244619 bp, + strand Genetic Position: Chr10, 32.57 cM, cytoband B4
• Alliance: Dnajc12^em1.1Mjfa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination inserted loxP sites flanking exon 2. Cre-mediated recombination deleted exon 2. Genomic PCR and western blot analysis confirmed the absence of expression in midbrain and striatum from homozygous mice. (J:376259)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnajc12 Mutation: 18 strains or lines available

References

• Original: J:376259 Deng IB, et al., Central biogenic amine deficiency with concomitant exploratory behavioral deficits in Dnajc12 knock-out mice. NPJ Parkinsons Dis. 2025 May 30;11(1):143
• All: 1 reference(s)