Phenotypes associated with this allele

• Allele Symbol: Prkaa2^em1Smz
• Allele Name: endonuclease-mediated mutation 1, Shi-Min Zhao
• Allele ID: MGI:8276809
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkaa2^em1Smz/Prkaa2^em1Smz	C57BL/6J-Prkaa2^em1Smz	MGI:8276974

Genotype
MGI:8276974

hm1

• Allelic Composition: Prkaa2^em1Smz/Prkaa2^em1Smz
• Genetic Background: C57BL/6J-Prkaa2^em1Smz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:377422 )

N • normal fluid intake

N • normal behavior in open field test

impaired spatial learning ( J:377422 )

• reduced exploration of new arm in Y maze test

• increased escape latency in hidden platform Morris water maze test

• reduced time spent in correct quadrant and reduced number of platform crossovers in Morris water maze probe trial

abnormal sucrose solution preference ( J:377422 )

• decreased sucrose preference

abnormal response to novel object ( J:377422 )

• impaired recognition

impaired limb coordination ( J:377422 )

• reduced success rate in pole test

cellular

increased neuron apoptosis ( J:377422 )

• in hippocampus

nervous system

increased neuron apoptosis ( J:377422 )

• in hippocampus