Phenotypes associated with this allele

• Allele Symbol: Cisd3^em1.1Davis
• Allele Name: endonuclease-mediated mutation 1.1, Daniel Davis
• Allele ID: MGI:8273498
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cisd3^em1.1Davis/Cisd3^em1.1Davis	involves: BALB/cJ * C57BL/6J * C57BL/6NTac	MGI:8275621

Genotype
MGI:8275621

hm1

• Allelic Composition: Cisd3^em1.1Davis/Cisd3^em1.1Davis
• Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:376815 )

• life span of about 60 weeks

growth/size/body

decreased body size ( J:376815 )

• in both males and females

muscle

abnormal skeletal muscle fiber mitochondrial morphology ( J:376815 )

• mitochondria are abnormal and appear swollen with damaged crista

abnormal sarcomere morphology ( J:376815 )

♂ • shorter Z-line distance in sarcomeres in males

centrally nucleated skeletal muscle fibers ( J:376815 )

♂ • increase in the number of cells with centralized nuclei in males

abnormal muscle physiology ( J:376815 )

♂ • basal respiration, maximal respiration and spare respiratory capacity of muscle fibers is reduced and glycolytic capacity is increased

homeostasis/metabolism

increased iron level ( J:376815 )

• in muscle sections from males and females

behavior/neurological

decreased grip strength ( J:376815 )

• physically weaker with reduced grip strength

cellular

abnormal skeletal muscle fiber mitochondrial morphology ( J:376815 )

• mitochondria are abnormal and appear swollen with damaged crista

abnormal cellular respiration ( J:376815 )

♂ • basal respiration, maximal respiration and spare respiratory capacity of muscle fibers is reduced and glycolytic capacity is increased