Cisd3^em1.1Davis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cisd3^em1.1Davis
• Name: CDGSH iron sulfur domain 3; endonuclease-mediated mutation 1.1, Daniel Davis
• MGI ID: MGI:8273498
• Gene: Cisd3 Location: Chr11:97576652-97579447 bp, + strand Genetic Position: Chr11, 61.06 cM
• Alliance: Cisd3^em1.1Davis page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting floxed exon 2. Cre-mediated recombination removed exon 2. Protein blot analysis showed absence of CISD3 expression and increased CISD2 expression in quadriceps muscle from homozygous mice. (J:376815)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cisd3 Mutation: 11 strains or lines available

References

• Original: J:376815 Nechushtai R, et al., CISD3/MiNT is required for complex I function, mitochondrial integrity, and skeletal muscle maintenance. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2405123121
• All: 1 reference(s)