Phenotypes associated with this allele

• Allele Symbol: Blk^em1Hxzh
• Allele Name: endonuclease-mediated mutation 1, Hai-Xue Zheng
• Allele ID: MGI:8268541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Blk^em1Hxzh/Blk^em1Hxzh	C57BL/6J-Blk^em1Hxzh	MGI:8268624

Genotype
MGI:8268624

hm1

• Allelic Composition: Blk^em1Hxzh/Blk^em1Hxzh
• Genetic Background: C57BL/6J-Blk^em1Hxzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased inflammatory response ( J:375901 )

• spleen pDCs and primary B cells stimulated with IL-1beta or TLR ligands (R848, LPS, CpG-B) show impaired transcription of Tnfa and Cxcl10 genes and phosphorylation of p65 and IkappaBalpha indicating attenuated TLR/IL-1R-mediated inflammatory responses in these cells

• mice injected intraperitoneally with murine IL-1beta show lower induced levels of serum cytokines including TNFalpha and IL6

• mice injected intraperitoneally with murine IL-1beta plus D-galactosamine hydrocholoride, mice show lower percentage of IL-1beta-induced inflammatory lethality within 30 hours compared with wild-type mice

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:375901 )

• mice injected intraperitoneally with murine IL-1beta plus D-galactosamine hydrocholoride, mice show lower percentage of IL-1beta-induced inflammatory lethality within 30 hours compared with wild-type mice